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Nck2tm2Paw
Targeted Allele Detail
Nomenclature
Symbol: Nck2tm2Paw
Name: non-catalytic region of tyrosine kinase adaptor protein 2; targeted mutation 2, Tony Pawson
MGI ID: MGI:2667154
Synonyms: Nick2tau-lacZ
Gene: Nck2  Location: Chr1:43445483-43570518 bp, + strand  Genetic Position: Chr1, 23.18 cM, cytoband C1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83956
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Disruption caused by insertion of vector
 
Mutation detailsA tau-beta-galactosidase cassette replaced the C-terminal part of the first coding exon (amino acids 22-76) as well as part of the following intron. In the process most of an SH3 domain is eliminated. (J:83956)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 67 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nck2 Mutation:  9 strains or lines available
References
Original:  J:83956 Bladt F, et al., The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network. Mol Cell Biol. 2003 Jul;23(13):4586-97
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/07/2020
MGI 6.15
The Jackson Laboratory