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Targeted Allele Detail
Symbol: Gucy2ctm1Gar
Name: guanylate cyclase 2c; targeted mutation 1, David L Garbers
MGI ID: MGI:2665316
Synonyms: Gcc-, GC-C -
Gene: Gucy2c  Location: Chr6:136697285-136781765 bp, - strand  Genetic Position: Chr6, 66.67 cM
Germline Transmission:  Earliest citation of germline transmission: J:43046
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsExon 1 was disrupted by a neomycin selection cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of intestinal mucosal scrapings obtained from homozygous mutant mice. Total intestine mucosal guanylyl cyclase activity was reduced 16-fold relative to wild-type controls, whereas heat-stable enterotoxin (STa)-stimulable guanylyl cyclase activity was absent in mutant mice. (J:43046)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gucy2c Mutation:  3 strains or lines available
Phenotypic Similarity to Human Syndrome: Obesity and Metabolic Syndrome in homozygous mice (J:178241)

Original:  J:43046 Schulz S, et al., Disruption of the guanylyl cyclase-C gene leads to a paradoxical phenotype of viable but heat-stable enterotoxin-resistant mice. J Clin Invest. 1997 Sep 15;100(6):1590-5
All:  9 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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