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Gucy2ctm1Gar
Targeted Allele Detail
Nomenclature
Symbol: Gucy2ctm1Gar
Name: guanylate cyclase 2c; targeted mutation 1, David L Garbers
MGI ID: MGI:2665316
Synonyms: Gcc-, GC-C -
Gene: Gucy2c  Location: Chr6:136697285-136781765 bp, - strand  Genetic Position: Chr6, 66.67 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:43046
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gucy2c Mutation:  3 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Obesity and Metabolic Syndrome in homozygous mice (J:178241)

References
Original:  J:43046 Schulz S, et al., Disruption of the guanylyl cyclase-C gene leads to a paradoxical phenotype of viable but heat-stable enterotoxin-resistant mice. J Clin Invest. 1997 Sep 15;100(6):1590-5
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory