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Targeted Allele Detail
Symbol: Pthtm1Dgo
Name: parathyroid hormone; targeted mutation 1, David Goltzman
MGI ID: MGI:2665181
Synonyms: PTH-
Gene: Pth  Location: Chr7:113385580-113388570 bp, - strand  Genetic Position: Chr7, 59.19 cM, cytoband F
Skeletal phenotypes and tibial histology of Pthtm1Dgo/Pthtm1Dgo, Pthlhtm1Hmk/Pthlhtm1Hmk and Pthtm1Dgo/Pthtm1Dgo Pthlhtm1Hmk/Pthlhtm1Hmk mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:76407
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of exon 3 with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by immunohistochemistry of parathyroid glands. (J:76407)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pth Mutation:  11 strains or lines available
Original:  J:76407 Miao D, et al., Parathyroid hormone is essential for normal fetal bone formation. J Clin Invest. 2002 May;109(9):1173-82
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory