About   Help   FAQ
Hbegftm1Dcl
Targeted Allele Detail
Nomenclature
Symbol: Hbegftm1Dcl
Name: heparin-binding EGF-like growth factor; targeted mutation 1, David C Lee
MGI ID: MGI:2665039
Synonyms: HB-EGF-
Gene: Hbegf  Location: Chr18:36504929-36515805 bp, - strand  Genetic Position: Chr18, 19.46 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83820
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 and 2 were replaced with PGK-Neo, deleting the signal peptide, propeptide and inducing a frame shift to prevent translational readthrough. Northern blots confirmed the absence of gene transcripts. (J:83820)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Hbegf Mutation:  17 strains or lines available
References
Original:  J:83820 Jackson LF, et al., Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling. EMBO J. 2003 Jun 2;22(11):2704-16
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/11/2017
MGI 6.10
The Jackson Laboratory