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Targeted Allele Detail
Symbol: Hbegftm1Dcl
Name: heparin-binding EGF-like growth factor; targeted mutation 1, David C Lee
MGI ID: MGI:2665039
Synonyms: HB-EGF-
Gene: Hbegf  Location: Chr18:36504929-36515805 bp, - strand  Genetic Position: Chr18, 19.46 cM
Germline Transmission:  Earliest citation of germline transmission: J:83820
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1 and 2 were replaced with PGK-Neo, deleting the signal peptide, propeptide and inducing a frame shift to prevent translational readthrough. Northern blots confirmed the absence of gene transcripts. (J:83820)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Hbegf Mutation:  17 strains or lines available
Original:  J:83820 Jackson LF, et al., Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling. EMBO J. 2003 Jun 2;22(11):2704-16
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory