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Targeted Allele Detail
Symbol: Acetm4Keb
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; targeted mutation 4, Kenneth E Bernstein
MGI ID: MGI:2665017
Synonyms: ACE.4, KAP ACE
Gene: Ace  Location: Chr11:105858774-105880790 bp, + strand  Genetic Position: Chr11, 68.84 cM
Germline Transmission:  Earliest citation of germline transmission: J:82998
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neo cassette immediately followed by a 2.3 kb kidney androgen-regulated protein promoter was inserted downstream of the endogenous somatic promoter and upstream of exon 1. The construct was designed such that transcription of the somatic isoform would be controlled by the inserted promoter, which drives expression in proximal tubule epithelium and the uterus. Unexepectedly, expression was undetected in the absence of exogenous androgens. With exogenous androgens, renal expression was less than 2% wild type levels. (J:82998)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ace Mutation:  35 strains or lines available
Original:  J:82998 Cole JM, et al., New approaches to genetic manipulation of mice: tissue-specific expression of ACE. Am J Physiol Renal Physiol. 2003 Apr;284(4):F599-607
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory