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Targeted Allele Detail
Symbol: Klf4tm1.1Khk
Name: Kruppel-like factor 4 (gut); targeted mutation 1.1, Klaus H Kaestner
MGI ID: MGI:2664975
Synonyms: Klf4-
Gene: Klf4  Location: Chr4:55527143-55532466 bp, - strand  Genetic Position: Chr4, 29.76 cM
Germline Transmission:  Earliest citation of germline transmission: J:76493
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe floxed region encompassing exons 2 and 3 was excised from Klf4tm1Khk via cre-mediated recombination in the germline. Absence of gene expression was confirmed by in situ hybridization of colon sections. (J:76493)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Klf4 Mutation:  18 strains or lines available
Original:  J:76493 Katz JP, et al., The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development. 2002 Jun;129(11):2619-28
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory