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Tg(Foxa3-cre)1Khk
Transgene Detail
Summary
Symbol: Tg(Foxa3-cre)1Khk
Name: transgene insertion 1, Klaus H Kaestner
MGI ID: MGI:2664968
Synonyms: Foxa3cre, Foxa3.cre, Foxa3Cre, Foxa3-Cre, Tg(Foxa3-cre)1Khk
Transgene: Tg(Foxa3-cre)1Khk  Location: unknown  
Alliance: Tg(Foxa3-cre)1Khk page
Transgene
origin
Strain of Origin:  (DBA x C57BL/6)F1
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsThe transgenic construct consists of a 170 kb fragment containing a modified Foxa3 locus in which exon 2 has been replaced with an IRES-cre cassette. Cre activity was first detected 8.5 dpc in the anterior intestinal portal, and later in the entire gut endoderm from stomach to colon. Efficient cre-mediated recombination was demonstrated in the stomach, liver, pancreas, and colon. (J:96332)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Foxa3 (species not specified)
Summary of all recombinase alleles driven by Foxa3.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 419 assay results
Tumor Data
List all tumor models in MMHCdb carrying Tg(Foxa3-cre)1Khk
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:96332 Lee CS, et al., Foxa2 is required for the differentiation of pancreatic alpha-cells. Dev Biol. 2005 Feb 15;278(2):484-95
All:  36 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory