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Targeted Allele Detail
Symbol: Keratm1Cyl
Name: keratocan; targeted mutation 1, Chia-Yang Liu
MGI ID: MGI:2664936
Synonyms: Kera-
Gene: Kera  Location: Chr10:97607205-97613688 bp, + strand  Genetic Position: Chr10, 50.34 cM
Germline Transmission:  Earliest citation of germline transmission: J:83873
Parent Cell Line:  Duffy (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAbout 1 kb of intron 1 and all but the last 0.6kb of exon 2 were replaced with a neomycin-resistance gene inserted in antisense orientation. In-situ hybridization indicated no mRNA in the cornea of homozygous mutant mice and protein was undetectable by immunohistochemical staining or by Western blot analysis. (J:83873)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kera Mutation:  4 strains or lines available
Original:  J:83873 Liu CY, et al., Keratocan-deficient mice display alterations in corneal structure. J Biol Chem. 2003 Jun 13;278(24):21672-7
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory