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Actn4tm1Plk
Targeted Allele Detail
Nomenclature
Symbol: Actn4tm1Plk
Name: actinin alpha 4; targeted mutation 1, Martin R Pollak
MGI ID: MGI:2664917
Synonyms: Actn4-
Gene: Actn4  Location: Chr7:28893248-28962340 bp, - strand  Genetic Position: Chr7, 16.94 cM
Focal and segmental glomerulosclerosis in Actn4tm1Plk/Actn4tm1Plk kidneys over 10 weeks of age

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83911
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Actn4 Mutation:  63 strains or lines available
References
Original:  J:83911 Kos CH, et al., Mice deficient in alpha-actinin-4 have severe glomerular disease. J Clin Invest. 2003 Jun;111(11):1683-90
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory