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Tgfbr3tm1Stv
Targeted Allele Detail
Nomenclature
Symbol: Tgfbr3tm1Stv
Name: transforming growth factor, beta receptor III; targeted mutation 1, Kaye Stenvers
MGI ID: MGI:2664514
Synonyms: betaglycan-, TBRIII-
Gene: Tgfbr3  Location: Chr5:107106570-107289629 bp, - strand  Genetic Position: Chr5, 51.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83727
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA PGK-Neo expression cassette was inserted in the "sense" orientation into exon 2. Homologous recombination was verified by Southern blot analysis. Two weak bands representing aberrent transcripts were seen in northern blots of mRNA from embryos homozygous from the targeted gene. RT-PCR analysis confirmed that none of these transcripts represented wild-type mRNA and affinity labelling of embryo fibroblasts with TGFbetaI indicated that there was no binding to TGFbetaRIII. (J:83727)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tgfbr3 Mutation:  6 strains or lines available
References
Original:  J:83727 Stenvers KL, et al., Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos. Mol Cell Biol. 2003 Jun;23(12):4371-85
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory