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Transgene Detail
Symbol: Tg(DO11.10)10Dlo
Name: transgene insertion 10, Dennis Y Loh
MGI ID: MGI:2664398
Synonyms: CO11.10 TCR-alphabeta, DO.10 Tg, DO11, DO.11, DO-11.10, DO11.10, Do11.10 alphabetaTCR, Do11.10 alphabeta TCR, DO11.10 alphabeta-TCR, DO.11.10 TCR, DO11.10 TCR, DO11.10TCRalphabeta, DO11.10 TCR Tg, DO11 TCR, DO-Tg, OVA-TCRtg, Tg(DO11.10)Tcra/Tcrb, TgN(DO11.10)10Dlo, TgN(DO11.10)10Loh
Transgene: Tg(DO11.10)10Dlo  Location: unknown  Genetic Position: Chr18, Syntenic
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(DO11.10)10Dlo expresses 2 genes
Mutation detailsThe transgene contains rearranged Tcra and Tcrb genes and is expressed in the majority of T cells. These rearranged transgenes encode a chicken ovalbumin-specific MHC class II (I-Ad)-restricted T cell receptor. (J:25536, J:61321)
View phenotypes for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available

Mice carrying this MHC class II restricted rearranged T cell receptor transgene on a H2d background react to ovalbumin (OVA) peptide antigen. Intraperitoneal administration of OVA to transgenic mice results in a rapid deletion of the immature CD4+ CD8+ TCRlo thymocytes with progression to mature thymocytes. Apoptosis of cortical thymocytes in these mice occurs within 20 hours of treatment.

Original:  J:70572 Murphy KM, et al., Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. Science. 1990 Dec 21;250(4988):1720-3
All:  622 reference(s)

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MGI 6.01
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