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Prkcqtm1Litt
Targeted Allele Detail
Nomenclature
Symbol: Prkcqtm1Litt
Name: protein kinase C, theta; targeted mutation 1, Dan Littman
MGI ID: MGI:2664379
Synonyms: PKCtheta-, PKC-Theta-
Gene: Prkcq  Location: Chr2:11172108-11301222 bp, + strand  Genetic Position: Chr2, 8.42 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83922
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe exon encoding the ATP-binding site of the kinase domain (aa 396 - 451) was replaced with a neo cassette inserted by homologous recombination. Protein was undetected in thymocytes or T cells obtained from mutant mice. (J:83922)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prkcq Mutation:  4 strains or lines available
References
Original:  J:83922 Sun Z, et al., PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes. Nature. 2000 Mar 23;404(6776):402-7
All:  66 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory