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Trmq1C57BL/6J
QTL Variant Detail
Nomenclature
QTL variant: Trmq1C57BL/6J
Name: T cell ratio modifier QTL 1; C57BL/6J
MGI ID: MGI:2664289
QTL: Trmq1  Location: Chr6:146428986-146429238 bp  Genetic Position: Chr6, cM position of peak correlated region/allele: 77.7 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:77603

304 (C57BL/6J x DBA/2J)F2 animals and 261 (C57BL/6J x DBA/2J)F1 x DBA/2J backcross animals were screened for 84 microsatellite markers at an average spacing of 15 cM to map QTLs affecting CD4:CD8 T cell ratios. Parental strain C57BL/6J exhibits low CD4:CD8 T cell ratios compared to parental strain DBA/2J.

Trmq1 (T cell ratio modifier QTL 1) mapped to 74 cM on mouse Chromosome 6 with a LOD score of 4.6 at D6Mit15 in the F2 cross. The flanking markers for Trmq1 are D6Mit198 (67 cM) and D6Mit15 (74 cM). DBA/2J-derived alleles confer increased lymph node CD4:CD8 levels with dominant inheritance. Candidate genes mapping to the QTL interval of Trmq1 are Klra, Klrb1c, and Klrb1.

Trmq2 mapped to 52 cM on mouse Chromosome 2 with a LOD score of 3.4 at D2Mit483 andD2Mit207 in the backcross population. The flanking markers for Trmq2 are D2Mit61 (34 cM) and D2Mit17 (69 cM). C57BL/6J-derived alleles confer increased lymph node CD4:CD8 levels with dominant inheritance. Candidate genes mapping to the QTL interval of Trmq2 are CD44, Rag1, Rag2, H3, Brm, Ir2, Il1a, Il1b, H42, H44, H45, and Ir9.

References
Original:  J:77603 Myrick C, et al., Linkage analysis of variations in CD4:CD8 T cell subsets between C57BL/6 and DBA/2. Genes Immun. 2002 May;3(3):144-50
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory