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Carm1tm1Mtb
Targeted Allele Detail
Nomenclature
Symbol: Carm1tm1Mtb
Name: coactivator-associated arginine methyltransferase 1; targeted mutation 1, Mark T Bedford
MGI ID: MGI:2663959
Synonyms: Carm1-
Gene: Carm1  Location: Chr9:21546894-21589487 bp, + strand  Genetic Position: Chr9, 7.82 cM, cytoband A4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83623
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsAn frt-flanked neo cassette was inserted upstream of two exons encoding a portion of the cofactor binding domain (amino acids 117-187). Additionally, the inserted neo cassette and the two exons were flanked by a single loxP sites. Protein was undetected in homozygous mutant mice. (J:83623)
Phenotypes
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Expression
In Mice Carrying this Mutation: 13 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Carm1 Mutation:  68 strains or lines available
References
Original:  J:83623 Yadav N, et al., Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6464-8
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory