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Bcl11atm1Ngc
Targeted Allele Detail
Nomenclature
Symbol: Bcl11atm1Ngc
Name: B cell CLL/lymphoma 11A (zinc finger protein); targeted mutation 1, Neal G Copeland
MGI ID: MGI:2663941
Gene: Bcl11a  Location: Chr11:24078056-24174123 bp, + strand  Genetic Position: Chr11, 14.41 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83646
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 2.4 kb region containing exon 1 was deleted and replaced with a PGK-neo cassette via homologous recombination. Absence of gene expression was confirmed by Northern blot and immunohistochemical analysis of homozygous mutant brains. (J:83646)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bcl11a Mutation:  15 strains or lines available
References
Original:  J:83646 Liu P, et al., Bcl11a is essential for normal lymphoid development. Nat Immunol. 2003 Jun;4(6):525-32
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory