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Socs3tm2.1Wsa
Targeted Allele Detail
Nomenclature
Symbol: Socs3tm2.1Wsa
Name: suppressor of cytokine signaling 3; targeted mutation 2.1, Warren S Alexander
MGI ID: MGI:2663925
Synonyms: Socs3deltadel
Gene: Socs3  Location: Chr11:117966079-117970047 bp, - strand  Genetic Position: Chr11, 82.96 cM, cytoband E2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83645
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele is derived from Socs3tm2Wsa by mating mutant animals to cre deleter strain TgN(CMV-cre)1Cgn, which results in excision of the entire gene coding region and the PGK-neo selectable marker. (J:83645)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Socs3 Mutation:  14 strains or lines available
References
Original:  J:83645 Croker BA, et al., SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol. 2003 Jun;4(6):540-5
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory