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Notch2tm1.1Hhi
Targeted Allele Detail
Nomenclature
Symbol: Notch2tm1.1Hhi
Name: notch 2; targeted mutation 1.1, Hisamaru Hirai
MGI ID: MGI:2663710
Synonyms: Notch2f, Notch2tm1Hhi
Gene: Notch2  Location: Chr3:98013538-98150367 bp, + strand  Genetic Position: Chr3, 42.42 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83476
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsFlanking loxP sites and a PGK-neo cassette were introduced to the exons encoding the transmembrane domains. The selection cassette was subsequently deleted by transient expression of cre recombinase in correctly targeted ES cells, leaving loxP sites flanking the sequences encoding the transmembrane domain. (J:83476)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Notch2 Mutation:  9 strains or lines available
References
Original:  J:83476 Saito T, et al., Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity. 2003 May;18(5):675-85
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory