Epas1^tm1Pec
Targeted Allele Detail

Summary

• Symbol: Epas1^tm1Pec
• Name: endothelial PAS domain protein 1; targeted mutation 1, Peter Carmeliet
• MGI ID: MGI:2663583
• Synonyms: Hif2alpha^-
• Gene: Epas1 Location: Chr17:87061292-87140838 bp, + strand Genetic Position: Chr17, 56.9 cM
• Alliance: Epas1^tm1Pec page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83549
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 2 with a neomycin resistance cassette via homologous recombination. Exon 2 encodes the basic helix-loop-helix domain which is essential for DNA binding and dimerization. (J:83549)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Epas1 Mutation: 64 strains or lines available

References

• Original: J:83549 Brusselmans K, et al., Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. J Clin Invest. 2003 May;111(10):1519-27
• All: 8 reference(s)