Tg(Mpz-cre/ERT2)2Ueli
Transgene Detail
|
Symbol: |
Tg(Mpz-cre/ERT2)2Ueli |
Name: |
transgene insertion 2, Ueli Suter |
MGI ID: |
MGI:2663097 |
Synonyms: |
P0-CreERT2, P0Cx-CreERT2, Tg(Mpz-cre/ESR1)2Ueli |
Transgene: |
Tg(Mpz-cre/ERT2)2Ueli Location: unknown
|
Alliance: |
Tg(Mpz-cre/ERT2)2Ueli page
|
|
|
Transgene Type: |
|
Transgenic (Inducible, Recombinase) |
Inducer: |
|
tamoxifen |
Mutation: |
|
Insertion
|
|
|
Tg(Mpz-cre/ERT2)2Ueli expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Homolog in Mouse |
Note |
rat |
Mpz (24564) |
|
|
|
|
|
Mutation details: 1.1 kb of rat Mpz promoter sequences control the expression of 350 bp from the 5' untranslated region of the human GJB1 gene and a cre-ESR1 cassette in Schwann cells. The GJB1 region includes exon 1, intron 1, and exon 2. The human ESR1 sequence is mutated at G400V, M543A, and L540A in the ligand-binding domain to allow activation by 4-hydroxytamoxifen (OHT) and ICI 182,780.
(J:83361)
|
|
|
Activity: |
Tissue activity of this recombinase allele
|
Driver:
|
Mpz
(rat)
|
|
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
Original: |
J:83361 Leone DP, et al., Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells. Mol Cell Neurosci. 2003 Apr;22(4):430-40 |
All: |
10 reference(s) |
|