Spag6l^tm1Jfs
Targeted Allele Detail

Summary

• Symbol: Spag6l^tm1Jfs
• Name: sperm associated antigen 6-like; targeted mutation 1, Jerome F Strauss III
• MGI ID: MGI:2662475
• Synonyms: Spag6^-
• Gene: Spag6l Location: Chr16:16570880-16647227 bp, - strand Genetic Position: Chr16, 10.39 cM
• Alliance: Spag6l^tm1Jfs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78433
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a beta-geo cassette inserted by homologous recombination. Transcript was undetected in the testes of homozygous mutant mice by Northern blot analysis. Western blot analysis indicated an absence of full length and truncated protein. (J:78433)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spag6l Mutation: 53 strains or lines available

References

• Original: J:78433 Sapiro R, et al., Male infertility, impaired sperm motility, and hydrocephalus in mice deficient in sperm-associated antigen 6. Mol Cell Biol. 2002 Sep;22(17):6298-305
• All: 13 reference(s)