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Targeted Allele Detail
Symbol: Ica1tm1Mdos
Name: islet cell autoantigen 1; targeted mutation 1, H Michael Dosch
MGI ID: MGI:2662437
Synonyms: ICA69null
Gene: Ica1  Location: Chr6:8630527-8778488 bp, - strand  Genetic Position: Chr6, 4.38 cM, cytoband A1-A2
Germline Transmission:  Earliest citation of germline transmission: J:83526
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe gene was disrupted by insertion of a tTA-neo cassette into the Tep69 epitope sequence of exon 2 via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of brain and salivary gland proteins. (J:83526)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ica1 Mutation:  30 strains or lines available
Original:  J:83526 Winer S, et al., ICA69(null) nonobese diabetic mice develop diabetes, but resist disease acceleration by cyclophosphamide. J Immunol. 2002 Jan 1;168(1):475-82
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory