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Sh2b1tm1Ayos
Targeted Allele Detail
Nomenclature
Symbol: Sh2b1tm1Ayos
Name: SH2B adaptor protein 1; targeted mutation 1, Akihiko Yoshimura
MGI ID: MGI:2662436
Synonyms: Sh2B-
Gene: Sh2b1  Location: Chr7:126466994-126475424 bp, - strand  Genetic Position: Chr7, 69.06 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78931
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
 
Mutation detailsA genomic fragment extending from within exon 2 through exon 8 was replaced with a PGK-neo cassette inserted by homologous recombination. The deleted region encoded the PH and SH2 domains of the protein. Transcript was undetected in the cerebellums of homozygous mutant mice by Northern blot analysis. (J:78931)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sh2b1 Mutation:  10 strains or lines available
References
Original:  J:78931 Ohtsuka S, et al., SH2-B is required for both male and female reproduction. Mol Cell Biol. 2002 May;22(9):3066-77
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory