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Targeted Allele Detail
Symbol: Sh2b1tm1Ayos
Name: SH2B adaptor protein 1; targeted mutation 1, Akihiko Yoshimura
MGI ID: MGI:2662436
Synonyms: Sh2B-
Gene: Sh2b1  Location: Chr7:126066166-126074596 bp, - strand  Genetic Position: Chr7, 69.06 cM
Germline Transmission:  Earliest citation of germline transmission: J:78931
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
Mutation detailsA genomic fragment extending from within exon 2 through exon 8 was replaced with a PGK-neo cassette inserted by homologous recombination. The deleted region encoded the PH and SH2 domains of the protein. Transcript was undetected in the cerebellums of homozygous mutant mice by Northern blot analysis. (J:78931)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sh2b1 Mutation:  17 strains or lines available
Original:  J:78931 Ohtsuka S, et al., SH2-B is required for both male and female reproduction. Mol Cell Biol. 2002 May;22(9):3066-77
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory