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Targeted Allele Detail
Symbol: Slit3tm1Dor
Name: slit guidance ligand 3; targeted mutation 1, David M Ornitz
MGI ID: MGI:2662346
Synonyms: Slit3-
Gene: Slit3  Location: Chr11:35121456-35708507 bp, + strand  Genetic Position: Chr11, 20.29 cM, cytoband A5
Congenital diaphragmatic hernia (CDH) and lung pathology in Slit3tm1Dor/Slit3tm1Dor mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:83292
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 3' portion of exon 1 (194 nt) was replaced along with approximately 800 nt of intron 1 by a cassette containing Beta-gal followed by floxed neo. The deleted sequence encoded the putative signal peptide, from the start codon to the first leucine-rich repeat. Endogenous transcript was undetected in homozygous mutant mice by RNase protection. The expression pattern of Beta-gal was similar to that of the endogenous gene. (J:83292)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slit3 Mutation:  53 strains or lines available
Original:  J:83292 Yuan W, et al., A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5217-22
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory