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Targeted Allele Detail
Symbol: Slit3tm1Dor
Name: slit guidance ligand 3; targeted mutation 1, David M Ornitz
MGI ID: MGI:2662346
Synonyms: Slit3-
Gene: Slit3  Location: Chr11:35121224-35708507 bp, + strand  Genetic Position: Chr11, 20.29 cM, cytoband A5
Congenital diaphragmatic hernia (CDH) and lung pathology in Slit3tm1Dor/Slit3tm1Dor mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:83292
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 3' portion of exon 1 (194 nt) was replaced along with approximately 800 nt of intron 1 by a cassette containing Beta-gal followed by floxed neo. The deleted sequence encoded the putative signal peptide, from the start codon to the first leucine-rich repeat. Endogenous transcript was undetected in homozygous mutant mice by RNase protection. The expression pattern of Beta-gal was similar to that of the endogenous gene. (J:83292)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slit3 Mutation:  46 strains or lines available
Original:  J:83292 Yuan W, et al., A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5217-22
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory