About   Help   FAQ
Slit3tm1Dor
Targeted Allele Detail
Summary
Symbol: Slit3tm1Dor
Name: slit guidance ligand 3; targeted mutation 1, David M Ornitz
MGI ID: MGI:2662346
Synonyms: Slit3-
Gene: Slit3  Location: Chr11:35012283-35599334 bp, + strand  Genetic Position: Chr11, 20.29 cM, cytoband A5
Alliance: Slit3tm1Dor page
Congenital diaphragmatic hernia (CDH) and lung pathology in Slit3tm1Dor/Slit3tm1Dor mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83292
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 3' portion of exon 1 (194 nt) was replaced along with approximately 800 nt of intron 1 by a cassette containing Beta-gal followed by floxed neo. The deleted sequence encoded the putative signal peptide, from the start codon to the first leucine-rich repeat. Endogenous transcript was undetected in homozygous mutant mice by RNase protection. The expression pattern of Beta-gal was similar to that of the endogenous gene. (J:83292)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slit3 Mutation:  80 strains or lines available
References
Original:  J:83292 Yuan W, et al., A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5217-22
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory