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Adcy5tm1Yish
Targeted Allele Detail
Nomenclature
Symbol: Adcy5tm1Yish
Name: adenylate cyclase 5; targeted mutation 1, Yoshihiro Ishikawa
MGI ID: MGI:2662295
Synonyms: AC5-, AC5KO, AC5 KO
Gene: Adcy5  Location: Chr16:35155636-35304549 bp, + strand  Genetic Position: Chr16, 24.71 cM, cytoband B-5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83301
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was disrupted by a neomycin selection inserted by homologous recombination. A putative additional downstream translational start site was deleted upon recombination of the targeting vector. (J:83301)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 8 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adcy5 Mutation:  26 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Parkinson Disease (J:83301)
References
Original:  J:83301 Iwamoto T, et al., Motor dysfunction in type 5 adenylyl cyclase-null mice. J Biol Chem. 2003 May 9;278(19):16936-40
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory