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Nociq2A/J
QTL Variant Detail
Summary
QTL variant: Nociq2A/J
Name: nociceptive sensitivity inflammatory QTL 2; A/J
MGI ID: MGI:2661861
QTL: Nociq2  Location: Chr10:122041304-122041528 bp  Genetic Position: Chr10, cM position of peak correlated region/allele: 70.36 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  A/J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers decreased sensitivity to formalin-induced nociception. (J:79707)
Inheritance:    Other (see notes)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:79707

203 (C57BL/6J x A/J)F2 mice were screened for 90 microsatellite markers at an average spacing of 22 cM to identify QTLs associated with formalin-induced nociception. Parental strain C57BL/6J is more sensitive to formalin-induced nociception compared to parental strain A/J. Two significant QTLs, Nociq1 and Nociq2, mapped to 55 cM on mouse Chromosome 9 and to 69 cM on mouse Chromosome 10, respectively. Nociq1 has a QTL range of 44 cM - 68 cM and gives a peak LOD score of 5.2 at D9Mit182. C57BL/6J-derived alleles confer increased hindlimb licking 0-10 minutes after formalin injection (early/acute phase) with dominant inheritance. Nociq2 has a QTL range of 34 cM - tel and gives a peak LOD score of 4.3 at D10Mit35a. C57BL/6J-derived alleles confer increased hindlimb licking 0-10 minutes (early/acute phase) and 10-90 minutes (late phase) after formalin injection. Nociq2 exhibits either dominant or additive inheritance.

References
Original:  J:79707 Wilson SG, et al., Identification of quantitative trait loci for chemical/inflammatory nociception in mice. Pain. 2002 Apr;96(3):385-91
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory