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Ace2tm1Pngr
Targeted Allele Detail
Nomenclature
Symbol: Ace2tm1Pngr
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; targeted mutation 1, Josef M Penninger
MGI ID: MGI:2661723
Gene: Ace2  Location: ChrX:164139332-164188420 bp, + strand  Genetic Position: ChrX, 76.12 cM, cytoband F5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77232
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 9 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region (nt 1069 through 1299) encoded the zinc binding catalytic domain. Northern and Western blot analyses indicated that neither transcript nor protein are produced by the mutant allele. (J:77232)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ace2 Mutation:  11 strains or lines available
References
Original:  J:77232 Crackower MA, et al., Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature. 2002 Jun 20;417(6891):822-8
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory