Circp2^CBA/J
QTL Variant Detail

Summary

• QTL variant: Circp2^CBA/J
• Name: circadian photosensitivity 2; CBA/J
• MGI ID: MGI:2661442
• QTL: Circp2 Location: Chr17:12198329-12198453 bp Genetic Position: Chr17, cM position of peak correlated region/allele: 8.14 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: CBA/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased circadian photosensitivity compared to C57BL/6J. (J:80788)
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:80788

218 animals from a (CBA/J-Pde6b^rd1/Pde6b^rd1 x C57BL/6J-Pde6b^rd1/Pde6b^rd1)F2 intercross were typed for 74 microsatellite markers at an average resolution of 15 cM to identify QTLs associated with circadian photosensitivity. Parental strain C57BL/6J-Pde6b^rd1/Pde6b^rd1 exhibits a greater phase shift of circadian rhythm locomotor activity when subjected to a monochromatic light pulse compared to parental strain CBA/J-Pde6b^rd1/Pde6b^rd1. Two significant QTLs were identified on mouse Chromosomes 12 and 17. Circp1 maps to 6 cM on Chromosome 12 with a LOD score of 3.5 at D12Mit170. CBA/J-derived alleles confer increased photosensitivity with recessive inheritance at Circp1. Circp2 maps to 10.5 cM on Chromosome 17 with a LOD score of 3.7 at D17Mit113. CBA/J-derived alleles confer increased photosensitivity with dominant inheritance at Circp2. A possible candidate gene for Circp2 is Junb. Further analysis revealed that Junb expression is significantly reduced in CBA/J-Pde6b^rd1/Pde6b^rd1 animals after exposure to light. Suggestive loci were also identified at 39.3 cM (D8Mit75, LOD=2.2) and 44 cM (D8Mit242, LOD=2.2) on mouse Chromosome 8, and at 23 cM (D12Mit54, LOD=2.7) on mouse Chromosome 12.

References

• Original: J:80788 Yoshimura T, et al., Mapping quantitative trait loci affecting circadian photosensitivity in retinally degenerate mice. J Biol Rhythms. 2002 Dec;17(6):512-9
• All: 1 reference(s)