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Rtn4tm2.1Matl
Targeted Allele Detail
Nomenclature
Symbol: Rtn4tm2.1Matl
Name: reticulon 4; targeted mutation 2.1, Marc Tessier-Lavigne
MGI ID: MGI:2661216
Synonyms: Nogo-
Gene: Rtn4  Location: Chr11:29692947-29744331 bp, + strand  Genetic Position: Chr11, 16.79 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83192
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe floxed neo cassette was excised from Rtn4tm2Matl via in vivo cre mediated recombination in the germline. The disrupted exon is encodes the first transmembrane domain of isoforms A, B, and C. (J:83192)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rtn4 Mutation:  105 strains or lines available
References
Original:  J:83192 Zheng B, et al., Lack of enhanced spinal regeneration in Nogo-deficient mice. Neuron. 2003 Apr 24;38(2):213-24
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory