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Targeted Allele Detail
Symbol: Ezh2tm1Tara
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit; targeted mutation 1, Alexander Tarakhovsky
MGI ID: MGI:2661097
Synonyms: Ezh2F, Ezh2fl
Gene: Ezh2  Location: Chr6:47530274-47595270 bp, - strand  Genetic Position: Chr6, 22.92 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:83216
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsFour exons encoding the SET domain were left flanked by single loxP sites after the insertion of targeting vector and subsequent in vitro excision of a floxed neo cassette. (J:83216)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 23 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ezh2 Mutation:  53 strains or lines available
Original:  J:83216 Su IH, et al., Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement. Nat Immunol. 2003 Feb;4(2):124-31
All:  65 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory