Grk6^tm1.1Mca
Targeted Allele Detail

Summary

• Symbol: Grk6^tm1.1Mca
• Name: G protein-coupled receptor kinase 6; targeted mutation 1.1, Marc G Caron
• MGI ID: MGI:2661089
• Synonyms: GRK6-, GRK6 KO, GRK6-KO
• Gene: Grk6 Location: Chr13:55592885-55608740 bp, + strand Genetic Position: Chr13, 30.06 cM, cytoband B1-3
• Alliance: Grk6^tm1.1Mca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83191
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The floxed region containing the neo-tk cassette and exons 3 through 9 was excised via cre mediated recombination in the germline. Protein was undetected by Western blot analysis of brainstem and striatum tissue obtained from homozygous mutant mice. Immunostaining confirmed the absence of protein in homozygous mutant striatal neurons. (J:83191)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grk6 Mutation: 36 strains or lines available

References

• Original: J:83191 Gainetdinov RR, et al., Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice. Neuron. 2003 Apr 24;38(2):291-303
• All: 18 reference(s)