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Targeted Allele Detail
Symbol: Mpltm1Wsa
Name: myeloproliferative leukemia virus oncogene; targeted mutation 1, Warren S Alexander
MGI ID: MGI:2660811
Synonyms: mpl -
Gene: Mpl  Location: Chr4:118442415-118457513 bp, - strand  Genetic Position: Chr4, 54.61 cM, cytoband D
Germline Transmission:  Earliest citation of germline transmission: J:32131
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced the first 5 coding exons and sequences containing the initiation codon and the transcription start site. Radioimmunoassays demonstrated that no functional protein was expressed on the cell surface of bone marrow or spleen cells derived from homozygous mice. (J:32131)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mpl Mutation:  2 strains or lines available
Original:  J:32131 Alexander WS, et al., Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl. Blood. 1996 Mar 15;87(6):2162-70
All:  39 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory