Ripk2^tm1Flv
Targeted Allele Detail

Summary

• Symbol: Ripk2^tm1Flv
• Name: receptor (TNFRSF)-interacting serine-threonine kinase 2; targeted mutation 1, Richard A Flavell
• MGI ID: MGI:2660793
• Synonyms: Card3 KO, RICK^-, Rip2^-
• Gene: Ripk2 Location: Chr4:16122733-16163647 bp, - strand Genetic Position: Chr4, 6.7 cM
• Alliance: Ripk2^tm1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75400
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exons 2 and 3 with a neomycin resistance gene by homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of thymocyte extracts. (J:75400, J:136572)

Tumor Data

List all tumor models in MMHCdb carrying Ripk2^tm1Flv

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ripk2 Mutation: 34 strains or lines available

References

• Original: J:75400 Kobayashi K, et al., RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature. 2002 Mar 14;416(6877):194-9
• All: 68 reference(s)