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Ripk2tm1Flv
Targeted Allele Detail
Nomenclature
Symbol: Ripk2tm1Flv
Name: receptor (TNFRSF)-interacting serine-threonine kinase 2; targeted mutation 1, Richard A Flavell
MGI ID: MGI:2660793
Synonyms: RICK-, Rip2-
Gene: Ripk2  Location: Chr4:16122733-16163647 bp, - strand  Genetic Position: Chr4, 6.7 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75400
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of exons 2 and 3 with a neomycin resistance gene by homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of thymocyte extracts. (J:75400, J:136572)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ripk2 Mutation:  14 strains or lines available
References
Original:  J:75400 Kobayashi K, et al., RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature. 2002 Mar 14;416(6877):194-9
All:  38 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/28/2017
MGI 6.11
The Jackson Laboratory