About   Help   FAQ
Targeted Allele Detail
Symbol: Pou3f3tm1Rmc
Name: POU domain, class 3, transcription factor 3; targeted mutation 1, Robert J McEvilly
MGI ID: MGI:2660725
Synonyms: Brn-1-
Gene: Pou3f3  Location: Chr1:42695768-42703176 bp, + strand  Genetic Position: Chr1, 21.21 cM
Germline Transmission:  Earliest citation of germline transmission: J:74989
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of sequences encoding the first 476 amino acids with a PGK-neo cassette via homologous recombination. The gene targeting event was confirmed by Southern blot analysis. Immunohistochemical analysis of homozygous mutant brains failed to detect protein product. (J:74989)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pou3f3 Mutation:  4 strains or lines available
Original:  J:74989 McEvilly RJ, et al., Transcriptional regulation of cortical neuron migration by POU domain factors. Science. 2002 Feb 22;295(5559):1528-32
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.12
The Jackson Laboratory