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Targeted Allele Detail
Symbol: H2dlAb1-Ea
Name: histocompatibility-2, MHC; targeted deletion, H2 complex
MGI ID: MGI:2658725
Synonyms: ABetao, (IA IE)null, IIdelta, MHC class IIdelta, MHC II-, MHCII-, MHC II0, MHC IIdelta, MHC-IIdelta, MHCIIdelta, MHC II KO
Gene: H2  Location: unknown  Genetic Position: Chr17, cytoband B-C
Germline Transmission:  Earliest citation of germline transmission: J:57484
Parent Cell Line:  H1 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Intergenic deletion
Mutation detailsA 78.8 kb deletion disrupting Class II MHC genes was induced in 129S2/SvPas-derived H1 embryonic stem (ES) cells via Cre recombination. A hygro-resistance cassette was inserted at the deletion site. The deletion spans from the second exon of the H2-Ab1 gene the third exon of the H2-Ea gene. The H2-Aa, H2-Eb1 and H2-Eb2 genes are completely deleted. (J:57484)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 12 strains available      Cell Lines: 0 lines available
Carrying any H2 Mutation:  264 strains or lines available
Original:  J:57484 Madsen L, et al., Mice lacking all conventional MHC class II genes. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10338-43
All:  159 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory