Tnfrsf21^tm1Vmd
Targeted Allele Detail

Summary

• Symbol: Tnfrsf21^tm1Vmd
• Name: tumor necrosis factor receptor superfamily, member 21; targeted mutation 1, Vishva Dixit
• MGI ID: MGI:2657184
• Synonyms: DR6^-
• Gene: Tnfrsf21 Location: Chr17:43327446-43400079 bp, + strand Genetic Position: Chr17, 19.69 cM, cytoband C
• Alliance: Tnfrsf21^tm1Vmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72761
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of a 3.9 kb region encompassing exons 2 and 3 with a neomycin resistance cassette via homologous recombination. The targeted mutation results in deletion of amino acids Q33-G415. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis of liver RNA. (J:72761)

Expression

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf21 Mutation: 61 strains or lines available

References

• Original: J:72761 Zhao H, et al., Impaired c-Jun Amino Terminal Kinase Activity and T Cell Differentiation in Death Receptor 6-deficient Mice. J Exp Med. 2001 Nov 19;194(10):1441-8
• All: 10 reference(s)