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Targeted Allele Detail
Symbol: Trpc2tm1Dlc
Name: transient receptor potential cation channel, subfamily C, member 2; targeted mutation 1, Catherine Dulac
MGI ID: MGI:2657154
Synonyms: TRP2-
Gene: Trpc2  Location: Chr7:102083116-102096396 bp, + strand  Genetic Position: Chr7, 54.71 cM, cytoband F1
Germline Transmission:  Earliest citation of germline transmission: J:74988
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of exons encoding transmembrane domains 4 and 5, part of a putative channel pore, and a conserved sequence motif (EWKFAR), with a floxed PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of vomeronasal organ extracts. (J:74988)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trpc2 Mutation:  63 strains or lines available
Original:  J:74988 Stowers L, et al., Loss of sex discrimination and male-male aggression in mice deficient for TRP2. Science. 2002 Feb 22;295(5559):1493-500
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory