About   Help   FAQ
Trpc2tm1Dlc
Targeted Allele Detail
Nomenclature
Symbol: Trpc2tm1Dlc
Name: transient receptor potential cation channel, subfamily C, member 2; targeted mutation 1, Catherine Dulac
MGI ID: MGI:2657154
Synonyms: TRP2-
Gene: Trpc2  Location: Chr7:102083116-102096396 bp, + strand  Genetic Position: Chr7, 54.71 cM, cytoband F1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:74988
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of exons encoding transmembrane domains 4 and 5, part of a putative channel pore, and a conserved sequence motif (EWKFAR), with a floxed PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of vomeronasal organ extracts. (J:74988)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trpc2 Mutation:  87 strains or lines available
References
Original:  J:74988 Stowers L, et al., Loss of sex discrimination and male-male aggression in mice deficient for TRP2. Science. 2002 Feb 22;295(5559):1493-500
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/14/2017
MGI 6.08
The Jackson Laboratory