Gpc3^tm1Arge
Targeted Allele Detail

Summary

• Symbol: Gpc3^tm1Arge
• Name: glypican 3; targeted mutation 1, Argiris Efstratiadis
• MGI ID: MGI:2657134
• Synonyms: Gpc3^-, Gpc3^deltaex1
• Gene: Gpc3 Location: ChrX:51361303-51702827 bp, - strand Genetic Position: ChrX, 28.74 cM, cytoband A3.3
• Alliance: Gpc3^tm1Arge page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75054
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encompassing a portion of the putative promoter region and all of exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by Northern blot analysis of homozygous mutant embryos at E12.5. (J:75054)

Disease models

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpc3 Mutation: 17 strains or lines available

References

• Original: J:75054 Chiao E, et al., Overgrowth of a mouse model of the Simpson-Golabi-Behmel syndrome is independent of IGF signaling. Dev Biol. 2002 Mar 1;243(1):185-206
• All: 1 reference(s)