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Targeted Allele Detail
Symbol: Nr1i3tm1Ddm
Name: nuclear receptor subfamily 1, group I, member 3; targeted mutation 1, David D Moore
MGI ID: MGI:2657124
Synonyms: CAR-
Gene: Nr1i3  Location: Chr1:171213970-171220701 bp, + strand  Genetic Position: Chr1, 79.21 cM
Germline Transmission:  Earliest citation of germline transmission: J:65416
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of exon 1 and exon 2 (which encodes part of the DNA-binding domain) with a lacZ-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot analysis. (J:65416)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr1i3 Mutation:  10 strains or lines available
Original:  J:65416 Wei P, et al., The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature. 2000 Oct 19;407(6806):920-3
All:  45 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory