About   Help   FAQ
The MGI survey is now closed.
Thanks for your support!
Targeted Allele Detail
Symbol: Loxtm1Ikh
Name: lysyl oxidase; targeted mutation 1, Ian K Hornstra
MGI ID: MGI:2657016
Synonyms: LOX-
Gene: Lox  Location: Chr18:52516069-52529867 bp, - strand  Genetic Position: Chr18, 28.22 cM
Thoracic aorta abnormalities in Loxtm1Ikh/Loxtm1Ikh mice

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:82926
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe gene was disrupted by insertion of a PGK-neo cassette into exon 1 via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot analysis. (J:82926)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lox Mutation:  2 strains or lines available
Original:  J:82926 Hornstra IK, et al., Lysyl oxidase is required for vascular and diaphragmatic development in mice. J Biol Chem. 2003 Apr 18;278(16):14387-93
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 5.21
The Jackson Laboratory