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Ahrtm1Yfk
Targeted Allele Detail
Nomenclature
Symbol: Ahrtm1Yfk
Name: aryl-hydrocarbon receptor; targeted mutation 1, Yoshiaki Fujii-Kuriyama
MGI ID: MGI:2657000
Synonyms: Ahr-, Ahr KO
Gene: Ahr  Location: Chr12:35497979-35534989 bp, - strand  Genetic Position: Chr12, 15.78 cM
Urate stones in the urinary bladder of Ahrtm1Yfk/Ahrtm1Yfk mice

Show the 5 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:46346
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsThe gene was disrupted by introducing an in-frame lacZ-neo fusion to exon 1 via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis of liver RNA. (J:46346)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Ahr Mutation:  74 strains or lines available
References
Original:  J:46346 Mimura J, et al., Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor. Genes Cells. 1997 Oct;2(10):645-54
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory