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Targeted Allele Detail
Symbol: Atp2a1tm1Dhm
Name: ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; targeted mutation 1, David H MacLennon
MGI ID: MGI:2656945
Synonyms: SERCA1-, SERCA1-null
Gene: Atp2a1  Location: Chr7:126445858-126463108 bp, - strand  Genetic Position: Chr7, 69.04 cM
Atp2a1tm1Dhm/Atp2a1tm1Dhm newborns are cyanotic

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:82947
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of exons 1-4 with a PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot and RT-PCR analysis. (J:82947)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atp2a1 Mutation:  26 strains or lines available
Original:  J:82947 Pan Y, et al., Targeted disruption of the ATP2A1 gene encoding the sarco(endo)plasmic reticulum Ca2+ ATPase isoform 1 (SERCA1) impairs diaphragm function and is lethal in neonatal mice. J Biol Chem. 2003 Apr 11;278(15):13367-75
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory