About   Help   FAQ
Portm2Wolf
Targeted Allele Detail
Nomenclature
Symbol: Portm2Wolf
Name: P450 (cytochrome) oxidoreductase; targeted mutation 2, C Roland Wolf
MGI ID: MGI:2656920
Synonyms: CPR-
Gene: Por  Location: Chr5:135670033-135735326 bp, + strand  Genetic Position: Chr5, 75.34 cM, cytoband G1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82951
Parent Cell Line:  GK129 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA floxed neo cassette was introduced into intron 4 and a single loxP site was introduced into intron 15 via homologous recombination. Transient expression of cre recombinase in correctly targeted ES cells resulted in deletion of the neo cassette and exons 5-15. (J:82951)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Por Mutation:  52 strains or lines available
References
Original:  J:82951 Henderson CJ, et al., Inactivation of the hepatic cytochrome p450 system by conditional deletion of hepatic cytochrome p450 reductase. J Biol Chem. 2003 Apr 11;278(15):13480-6
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/10/2018
MGI 6.12
The Jackson Laboratory