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Sepp1tm1Rfb
Targeted Allele Detail
Nomenclature
Symbol: Sepp1tm1Rfb
Name: selenoprotein P, plasma, 1; targeted mutation 1, Raymond F Burk
MGI ID: MGI:2656912
Synonyms: Sepp-
Gene: Sepp1  Location: Chr15:3268547-3280507 bp, + strand  Genetic Position: Chr15, 1.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82921
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe gene was disrupted by insertion of a neomycin resistance cassette into exon 2 via homologous recombination. The neo cassette carries stop codons in all 3 reading frames. Protein product was undetectable by Western blot and radioimmunoassay of plasma samples from homozygous mutant animals. (J:82921)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sepp1 Mutation:  11 strains or lines available
References
Original:  J:82921 Hill KE, et al., Deletion of selenoprotein P alters distribution of selenium in the mouse. J Biol Chem. 2003 Apr 18;278(16):13640-6
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory