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Lbm3MRL/MpJ
QTL Variant Detail
Summary
QTL variant: Lbm3MRL/MpJ
Name: lean body mass 3; MRL/MpJ
MGI ID: MGI:2656835
QTL: Lbm3  Location: unknown  Genetic Position: Chr6, Syntenic
Variant
origin
Strain of Specimen:  MRL/MpJ
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased lean body mass compared to SJL/J. (J:81606)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:81606

Genome scan was performed on 633 (MRL/MpJ x SJL/J)F2 animals to identify QTLs associated with lean body mass and body length. Parental strain MRL/MpJ exhibits a higher amount of lean body mass compared to parental strain SJL/J. Several lean body mass (Lbm) and body length (Lgth) QTLs were mapped. MRL/MpJ-derived alleles confer increased lean body mass at all Lbm loci. Lbm1, Lbm2, Lgth1, and Lgth2 map to mouse Chromosome 2 at 26.3 cM (LOD=3.6) , 50.3 cM (LOD=9.0), 50.3 cM (LOD=10.8), and 72.1 cM (LOD=9.7), respectively. (Lbm2 and Lgth1 overlap.) Lbm1 is inherited additively while Lbm2 is inherited dominantly. Lgth3 maps to 30.6 cM on mouse Chromosome 4 with LOD=2.7 at D4Mit178. Lbm3 and Lbm4 map to mouse Chromosome 6 at 17.5 cM (LOD=4.7) and 49.2 cM (LOD=4.7), respectively. Lbm3 exhibits a dominant mode of inheritance and Lbm4 exhibits an additive mode of inheritance. Lbm5 maps to 8 cM on mouse Chromosome 7 with LOD=2.9 at D7Mit22 and exhibits an additive mode of inheritance. Lbm6 and Lgth4 both map to 7.7 cM (LOD=7.5 and LOD=4.7, respectively), and Lbm7 and Lgth5 both map to 31.7 cM (LOD=4.7 and LOD=2.3, respectively) on mouse Chromosome 9. Lbm6 and Lbm7 exhibit dominant inheritance. Lgth6 maps to 43.7 cM on mouse Chromosome 11 with LOD=4.8 at D11Mit36. Lbm8and Lgth8 both map to 23 cM (LOD=4.2 and LOD=2.3, respectively), and Lbm9 and Lgth7 both map to 2.2 cM (LOD=3.9 and LOD=2.7, respectively) on mouse Chromosome 13. Lbm8 and Lbm9 exhibit additive inheritance. Lbm10 maps to 40.4 cM on mouse Chromosome 14with LOD=4.7 at D14Mit32 and exhibits additive inheritance.

References
Original:  J:81606 Masinde GL, et al., Quantitative trait loci (QTL) for lean body mass and body length in MRL/MPJ and SJL/J F(2) mice. Funct Integr Genomics. 2002 Aug;2(3):98-104
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory