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Targeted Allele Detail
Symbol: Mrc1tm1Jub
Name: mannose receptor, C type 1; targeted mutation 1, Jacques U Baenziger
MGI ID: MGI:2656742
Synonyms: M/G4S-R-
Gene: Mrc1  Location: Chr2:14229414-14332023 bp, + strand  Genetic Position: Chr2, 10.46 cM
Germline Transmission:  Earliest citation of germline transmission: J:74332
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of exon 2 with a PGK-neo cassette via homologous recombination. Exon 2 was chosen for targeting because it encodes the entire cysteine-rich domain of the receptor and is the longest contiguous coding sequence. (J:74332)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mrc1 Mutation:  2 strains or lines available
Original:  J:74332 Mi Y, et al., Regulation of lutropin circulatory half-life by the mannose/N-acetylgalactosamine-4-SO4 receptor is critical for implantation in vivo. J Clin Invest. 2002 Jan;109(2):269-76
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory