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QTL Variant Detail
QTL variant: Cia20BALB/cCrl
Name: collagen induced arthritis QTL 20; BALB/cCrl
MGI ID: MGI:2656558
QTL: Cia20  Location: Chr1:8203006-8203185 bp  Genetic Position: Chr1, Syntenic
Strain of Specimen:  BALB/cCrl
Allele Type:    QTL

Mapping and Phenotype information for this QTL, its variants and associated markers


135 SSLP markers were screened in a set of 939 (BALB/cCrl x DBA/1J)F2 intercross animals to identify QTLs associated with collagen-induced arthritis (CIA) and proteoglycan-induced arthritis (PGIA). Parental strain BALB/cCrl is CIA-resistant and PGIA-susceptible while parental strain DBA/1J is CIA-susceptible and PGIA-resistant.

Two novel loci associated with CIA mapped to mouse Chromosome 1.

Cia20 (mCia14) mapped to peak marker D1Mit65 at approximately 8 cM. Cia20 is linked to IFN-gamma production (LOD=2.9).

Cia15 (mCia15) mapped to an interval spanning 33cM - 54cM, flanked by markers D1Mit76 and D1Mit48, and is linked to soluble CD44 production (LOD=2.8).

Original:  J:82018 Adarichev VA, et al., Combined autoimmune models of arthritis reveal shared and independent qualitative (binary) and quantitative trait loci. J Immunol. 2003 Mar 1;170(5):2283-92
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
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