Cia15^DBA/1J
QTL Variant Detail

Summary

• QTL variant: Cia15^DBA/1J
• Name: collagen induced arthritis QTL 15; DBA/1J
• MGI ID: MGI:2656555
• QTL: Cia15 Location: Chr1:65889006-88496101 bp Genetic Position: Chr1, cM position of peak correlated region/allele: 2.08 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: DBA/1J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:82018

135 SSLP markers were screened in a set of 939 (BALB/cCrl x DBA/1J)F2 intercross animals to identify QTLs associated with collagen-induced arthritis (CIA) and proteoglycan-induced arthritis (PGIA). Parental strain BALB/cCrl is CIA-resistant and PGIA-susceptible while parental strain DBA/1J is CIA-susceptible and PGIA-resistant.

Two novel loci associated with CIA mapped to mouse Chromosome 1.

Cia20 (mCia14) mapped to peak marker D1Mit65 at approximately 8 cM. Cia20 is linked to IFN-gamma production (LOD=2.9).

Cia15 (mCia15) mapped to an interval spanning 33cM - 54cM, flanked by markers D1Mit76 and D1Mit48, and is linked to soluble CD44 production (LOD=2.8).

References

• Original: J:82018 Adarichev VA, et al., Combined autoimmune models of arthritis reveal shared and independent qualitative (binary) and quantitative trait loci. J Immunol. 2003 Mar 1;170(5):2283-92
• All: 1 reference(s)