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Transgenic Allele Detail
Symbol: Edil3Tg(Sox2-cre)1Amc
Name: EGF-like repeats and discoidin I-like domains 3; transgene insertion 1, Andrew P McMahon
MGI ID: MGI:2656539
Synonyms: Sox2-cre, Sox2Cre, Sox2::Cre, Sox2-Cretg, Tg(Sox2-cre)1Amc
Gene: Edil3  Location: Chr13:88821472-89323223 bp, + strand  Genetic Position: Chr13, 45.3 cM, cytoband C3
Strain of Origin:  (C57BL/6 x CBA)F1
Transgene Type:    Transgenic (Null/knockout, Recombinase)
Mutation:    Insertion
Mutation detailsThis transgene expresses Cre recombinase under the control of a mouse Sox2 promoter contained in 12.5 kb of upstream DNA. Expression of this transgene is sex-dependent, with increased efficiency when passed through the female germline. When the transgene is passed through the male germline, cre activity is observed in epiblast cells as early as E6.5 of only those embryos that inherit the transgene and no expression is detected in extraembryonic tissue. When the transgene is passed through the female germline, cre activity is observed throughout the embryo (including the yolk sac) in all early embryos regardless of whether or not they inherit the transgene. Line 1 inserted into an intron of the gene at 89311726-89311727 (Build GRCm38/mm10) resulting in a functional knockout of the gene. Founder line 1 has a copy number of 2-5. (J:83040, J:86588, J:124941, J:134483, J:178271)
 Tissue activity of this recombinase allele
Driver: Sox2     Summary of all recombinase alleles driven by Sox2. Comparative matrix view of recombinase activities

View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 107 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Edil3 Mutation:  4 strains or lines available
Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.
Original:  J:83040 Hayashi S, et al., Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech Dev. 2002 Dec;119 Suppl 1:S97-S101
All:  362 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory