Tg(GFAP-cre)8Gtm
Transgene Detail

Summary

• Symbol: Tg(GFAP-cre)8Gtm
• Name: transgene insertion 8, David H Gutmann
• MGI ID: MGI:2656248
• Synonyms: GFAPCre, GFAP-Cre, GFAP-Cre-IRES-LacZ
• Transgene: Tg(GFAP-cre)8Gtm Location: unknown
• Alliance: Tg(GFAP-cre)8Gtm page

Transgene origin

• Strain of Origin: C57BL/6 x CBA

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(GFAP-cre)8Gtm expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  GFAP (2670)

  Gfap	(MGI:95697)

• Mutation details: This transgene expresses Cre recombinase and beta-galactosidase under the control of the human glial fibrillary acidic (GFAP) promoter. This transgene is expressed in astrocytes by embryonic day 14.5. Two lines 1 and 8 were analyzed further for cre activity and expression. Both gave identical results, with data for line 8 presented in the reference. (J:77208, J:185602)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	GFAP (human) Summary of all recombinase alleles driven by GFAP. Comparative matrix view of recombinase activities Alliance human GFAP gene page

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(GFAP-cre)8Gtm

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:77208 Bajenaru ML, et al., Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation. Mol Cell Biol. 2002 Jul;22(14):5100-13
• All: 49 reference(s)