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Targeted Allele Detail
Symbol: Tsc1tm1Djk
Name: TSC complex subunit 1; targeted mutation 1, David J Kwiatkowski
MGI ID: MGI:2656240
Synonyms: Tsc1c, Tsc1fl, Tsc1flox, Tsc1L, Tsc1lox
Gene: Tsc1  Location: Chr2:28531240-28581179 bp, + strand  Genetic Position: Chr2, 19.38 cM, cytoband B-C1.1
Alliance: Tsc1tm1Djk page
Brains of Tsc1tm1Djk/Tsc1tm1Djk Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+ mice injected with an adenovirus expressing cre recombinase show ventricular region abnormalities

Show the 5 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:82532
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA floxed neo-TK cassette was inserted into the intron preceding exon 17 and a third loxP site was introduced downstream of exon 18 by homologous recombination. (J:75243)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 47 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Tsc1tm1Djk
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tsc1 Mutation:  53 strains or lines available
Phenotypic Similarity to Human Syndrome: Angiosarcoma/Lymphangiosarcoma J: 231316.
Original:  J:82532 Uhlmann EJ, et al., Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures. Ann Neurol. 2002 Sep;52(3):285-96
All:  293 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory